CAVERA: Hydrogel Spray Combining Sea Lettuce (Ulvalactuca) and Aloe Vera (Aloe vera L) Extracts as an Anti-inflammatory and Antibacterial Agent for Atopic Dermatitis

Authors

  • Sang Ayu Putu Karunia Jayadi Putri Udayana University image/svg+xml Author

Keywords:

CAVERA, Atopic dermatitis, Sea Lettuce, Aloe Vera, Skin thickness

Abstract

Atopic dermatitis is a skin condition commonly experienced by people of all ages, with a prevalence of 15–20% worldwide. The standard treatment for this condition is Topical Corticosteroids (TCS). However, the use of corticosteroids can lead to non-adherence due to discomfort and local and systemic side effects. Given these limitations, a hydrogel spray formulation could be an appropriate solution. A combination of sea lettuce and aloe vera extracts was formulated into a hydrogel spray named CAVERA. In this study, three treatments were formulated based on varying concentrations of the extract combination. Phytochemical and FT- IR analysis of the extract revealed the presence of flavonoids (quercetin, kaempferol), tocopherols, tannins, saponins, triterpenoids, quinones (aloin and emodin), and polysaccharides (alpha-glycosides). Antibacterial testing of the extract combination against Staphylococcus aureus at a 100% concentration showed the highest inhibition zone, with a diameter of 19.57 mm. Homogeneous results were obtained in the CAVERA homogeneity test, and the results showed that C(-) and P1 were stable, while P2 and P3 were unstable in the stability test. pH values of 5.7, 5.3, and 5.2 were obtained, and only P1 fell within the viscosity range. In tests of spray patterns and formulation weight, the results showed that as viscosity decreased, so did the weight. In the organoleptic test, P1 was found to be the most preferred in terms of color, texture, and aroma. The effectiveness of CAVERA as a hydrogel spray was tested using an in vivo atopic dermatitis model in mice, and the results showed that P3 significantly reduced the thickness of the dorsal skin. In the scratching behavior test, the results showed a significant reduction in scratching behavior with P3 compared to CN. In the histological test, P3 showed a significant reduction in epidermal thickness and skin keratin on the back compared to C(-).

 

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2026-08-10

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Vol. 1 No. 1 (2026): Origo Medica Journal : Vol 1. No 1

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